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Do Women Build Up Marijuana Tolerance Faster Than Men?


old lady marijuanaSome of the hardest hitting marijuana consumers that I know are women. I know a few women that can out smoke any guy I know. They can eat more edibles, they can smoke more flower, and they can take more dab hits. For a long time I just thought that they were more hardcore than my guy friends. It turns out, science may be playing a role in their tolerance level. Per the Huffington Post:

Researchers at Washington State University have found evidence indicating that females may build up a tolerance to marijuana more easily than males do. While it’s not entirely predictive, people with an increased tolerance of a drug are more likely to become addicted to it — which means women may want to think twice before matching a man joint for joint.

The study focused on the pain-relieving effects of THC on male and female rats. In this case, rats made for good subjects, because, like humans, rats have a menstrual cycle (albeit one that lasts four to five days instead of 28), and they experience similar ovarian hormone fluctuations, which affect pain.

At the beginning of the trial, the female rats displayed a higher sensitivity to THC than the males. However, after 10 days of testing, researchers found that the female rats were needing higher doses of THC than the males just to experience the same degree of pain relief. In other words, while female rats started out being more sensitive to THC, after 10 days, they ended up less sensitive.

This test of course was on lab rats, but I’ve seen this theory in action with humans, as I stated at the beginning of this article. If you have a girlfriend that can out smoke you, don’t feel bad about it, it’s likely just science. Have readers experienced this first hand? Are you a woman that can out smoke your male friends and/or family members? If so, leave a comment.


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Johnny Green


  1. yup i’m a young woman ( in my 20’s) and I can outsmoke family and friends double my age, always thought it was just one of those things that I’ve smoked for awhile so I built up a decent tolerance, science can say that but I still say woman are just the better sex especially at smoking weed :P

  2. It is obvious you just don’t like that women can consistently outspoken you (; it is a fact yo, or do you not even have any female friends?

  3. It is obvious you just don’t like that women can consistently outspoken you (; it is a fact yo, or do you not even have any female friends?

  4. Yup, I’m a woman and I out smoke all the men I know, including my husband! I feel like I have a high tolerance and I build one up quickly after taking a tolerance break too. Maybe science, maybe just me. Maybe chicks just kick ass at smoking the ganj.

  5. These animal model studies typically use synthetic THC and not the whole cannabis plant with all of its mutually modulating cannabinoids, terpenes and other compounds.
    When these sort of studies are reported in the MSM they highlight sensationalist
    conclusions that are not necessarily definitive. Look up the actual report written by the researcher and you will often see that actual cannabis was not used. The devil is in the details.

  6. Which strain was given to the rats? What were the THC/CBD percentages? Perhaps that is where you will find the reason for the THC “sensitivity” of the female rats.

    The main difference between men and women when it comes to the effects of cannabis probably have to do with hormones… so research should look at the difference between age groups, not just between the sexes.

  7. Synthea Estrucian on

    I am a lightweight as are my girlfriends. Of course we don’t party every week so we may not fit the profile you are looking for. I have a few male friends who take a hit or 3 and face plant in their pancakes at the waffle house. After a couple tokes I have been known to laugh so hard I pass out but that is hyperventilation I believe. I suppose your mileage may vary depending on your level of use. I also have an older uncle that never left the 60s. He’s been stoned for 50 years. I don’t even think he gets high anymore, I think its just habit now, like breathing. I am due some vacation time so I may take the 10 day challenge with my boyfriend and see if I can smoke him into submission. Good thing I have a gym membership because I bet we make a huge dent in the snacks at the market.

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