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Study: Inhaled Cannabis Reduces Crohn’s Symptoms

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cannabinol cannabis marijuana crohns diseaseBy Paul Armentano, NORML Deputy Director

Inhaling cannabis reduces symptoms of Crohn’s disease compared to placebo in patients non-responsive to traditional therapies, according to clinical trial data published online ahead of print in the journal Clinical Gastroenterology and Hepatology.

Researchers at the Meir Medical Center, Department of Gastroenterology and Hepatology in Israel assessed the safety and efficacy of inhaled cannabis versus placebo in 21 subjects with Crohn’s disease who were nonresponsive to conventional treatments.

Eleven participants smoked standardized cannabis cigarettes containing 23 percent THC and 0.5 percent CBD (cannabidiol) twice daily over a period of eight weeks. The other ten subjects smoked placebo cigarettes containing no active cannabinoids.

Investigators reported, “Our data show that 8-weeks treatment with THC-rich cannabis, but not placebo, was associated with a significant decrease of 100 points in CDAI (Crohn’s Disease and activity index) scores.” (The CDIA is a research tool used to quantify the symptoms of Crohn’s disease patients.) Five of the eleven patients in the study group also reported achieving disease remission (defined as a reduction in patient CDAI score by more than 150 points).

Researchers also reported that “no significant side effects” were associated with cannabis inhalation. Subjects in the study group reported improvements in appetite and sleep compared to those in the placebo group. Cannabis inhalation was also associated with “significantly less pain” among the participants.

The study is the first placebo-controlled clinical trial to assess the consumption of cannabis for the treatment of Crohn’s.

Israeli researchers had previously published observational trial data reporting that Crohn’s patients require fewer disease-related surgeries following their use of cannabis.

According to survey data published in 2011 in the European Journal of Gastroenterology and Hepatology, some one-half of Crohn’s disease patients acknowledge having used cannabis to mitigate their disease symptoms.

Source: NORML - make a donation

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Johnny Green

3 Comments

  1. My father died at 49 due to crohns and the complications the disease caused. My father was also a daily marajuanna smoker up until age 34 when he lost his job of 15 years due to a positive marijuanna screen. In order for my father to go back to wrk as a master electrition he had to give up smoking marijuanna. He then replaced the calming effects from marijuanna with alcohol. Within 12 years of stopping the marijuanna my father was given two years to live. He died right at that two year mark, his death very agonizingly painful. Alcohol sped up and intensified his crohns but i still say had he not been forced to stop the marijuanna then he probably wouldnt have drank anywhere near as heavily as he did. My fathers last two months of life, after being awarded his disibility benefits, he then finally felt safe enough to once again ease his symptoms with marijuanna.

  2. I’ve had Crohns for 20 years now. My GI Dr wouldn’t even prescribe marinol. This data has been known by those with Crohns for years (if they tried it). I can testify it makes a huge difference in reducing pain, creates appetite & helps with sleep & I’m sure many more issues associated with this disease. I live in Washington thank God now, but the Western Medical teachings & Dr’s acceptance of this FACT will still take probably another ten years before they will acknowledge this fact Marijuana is medicine. I’m sure the pharmaceutical companies have been a huge part in keeping this suppressed. How will they make billions if your able to either by this affordable treatment or even more, grow it.

  3. The Israelis have their shit together when it comes to medical marijuana research. They even serve the lords plant to qualified senior citizens that have been placed in nursing homes, and the residents are loving it.

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