- The Weed Blog https://www.theweedblog.com

Study Shows Cannabidiol Mitigates Psychotic Symptoms In Schizophrenics


Medical LeafStudy: Administration Of Non-Psychotropic Cannabinoid Mitigates Psychotic Symptoms In Schizophrenics

The administration of the non-psychotropic plant constituent cannabidiol (CBD) is associated with a significant reduction in psychotic symptoms in patients with schizophrenia, according to clinical trial data published in the journal Translational Psychiatry.

An international team of researchers from Germany and the United States performed a four week, double-blind, randomized clinical trial assessing the clinical relevance of cannabidiol versus amisulpride, a potent antipsychotic agent, in patients with acute schizophrenia.

Researchers reported that the administration of either substance was associated with significant clinical improvement, but they acknowledged, “[C]annabidiol displayed a markedly superior side-effect profile.”

Amisulpride is categorized as “one of the most effective drugs currently in use for the treatment of schizophrenia.”

Investigators concluded, “Our results provide evidence that the non-cannabimimetic constituent of marijuana, cannabidiol, exerts clinically relevant antipsychotic effects that are associated with marked tolerability and safety, when compared with current medications. … The results … potentially represent a completely new mechanism in the treatment of schizophrenia.”

A review of CBD’s safety profile in humans, published online in 2011 in the scientific journal Current Drug Safety, concluded that the cannabinoid is non-toxic, safe, and well tolerated in humans, even in high doses.

Separate investigations of CBD have documented the cannabinoid to possess a variety of therapeutic properties, including anti-inflammatory, anti-diabetic, anti-epileptic, anti-cancer, and bone-stimulating properties.

For more information, please contact Paul Armentano, NORML Deputy Director, at: paul@norml.org. Full text of the study, “Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia,” is available online here: http://www.nature.com/tp/journal/v2/n3/full/tp201215a.html.

Article From NORML and republished with permission


About Author


  1. I don’t feed into it. There are lots of uninformed people who just want to argue. They really don’t care about the position, as long as they have one. I always try to redirect them to other issues they should focus on. In the end, I just want people to treat cannabis rationally. If that were the case, it wouldn’t be such a hot topic of discussion. When was the last time you heard of basil madness?

  2. DarkerMatter on

    I heard about this a long time ago, I guess its now scientifically official. 

    Mr Green (TWB) has so much knowledge about cannabis, I wonder how he handles sincere idiots who spout reefer madness propaganda?  It just irks me to the point I just shut down or change the subject. 

  3. We have CB1 and CB2 receptors, which occur naturally throughout our bodies. When we smoke ganja, THC binds to the CB1 receptor giving you the high, while CBD binds to the CB2 receptor giving you pain relief. Herbs like marijuana are the greatest medicines the earth has to offer us.

    I call it getting high, but Wikipedia calls it:

    Endocannabinoid-mediated depolarization-induced suppression of inhibition, a very common form of short-term plasticity in which the depolarization of a single neuron induces a reduction in GABA-mediated neurotransmission. Endocannabinoids released from the depolarized post-synaptic neuron bind to CB1 receptors in the pre-synaptic neuron and cause a reduction in GABA release.


     If you want a strain with high CBD check out Harlequin:https://www.theweedblog.com/harlequin-marijuana-strain-review-and-pictures/

Leave A Reply