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Study: THC Reduces Methamphetamine-Induced Brain Damage


Marijuana brain stressCourtesy of The Joint Blog

A new study published in this month’s issue of the journal PLoS ONE, and published online by the National Institute of Health, has found that THC (Δ9-tetrahydrocannabinol) can reduce and even prevent brain damage caused by methamphetamine intake.

According to the study, titled Δ9-tetrahydrocannabinol prevents methamphetamine-induced neurotoxicity, “Methamphetamine (METH) is a potent psychostimulant with neurotoxic properties. Heavy use increases the activation of neuronal nitric oxide synthase (nNOS), production of peroxynitrites, microglia stimulation, and induces hyperthermia and anorectic effects.” 

It continues; “Preclinical studies have shown that natural (Δ9-tetrahydrocannabinol, Δ9-THC) and synthetic cannabinoid CB1 and CB2 receptor agonists exert neuroprotective effects on different models of cerebral damage. Here, we investigated the neuroprotective effect of Δ9-THC on METH-induced neurotoxicity by examining its ability to reduce astrocyte activation and nNOS overexpression in selected brain areas.”

Using rat models, researchers discovered that; “Our results indicate that Δ9-THC reduces METH-induced brain damage via inhibition of nNOS expression and astrocyte activation through CB1-dependent and independent mechanisms, respectively.”

The full study can be found by clicking here.

Source: TheJointBlog.Com


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Johnny Green


  1. Ya I am 35 yes old and have dealt with 5 brain tumors from the age of ten been smoking since I was about 14 and never done any other drugs not even cancer sticks if u are going to do other drugs then u prob going to do them anyways. Going back for another brain surgery at U of M on 5-15-15 it will be my 5th or 6th one kinda lost count… I will be smoking pot to the day I die weather I have my card or not!!! Its funny how the try to lead people to believe pot is more harmful than cigs when they know they are not but push the pills but restrict medical studies on pot just look up a high CBD strain called “Charlotte’s web” named after a little girl in Denver who had like 200 seizures a day the parents were hoping she would pass away in her sleep peacefully.Now she is seizure free! :) sorry so long this subject hits close to home for me I been having them since I was 10 years old.

  2. They also said marajuana would cause brain damage. Wich we all know is a bunch of crap.

  3. Is this the same marijuana that has no medical benefits? Is this the same meth that the Feds rate (Schelule 2?) as less harmful than marijuana? Rhetorical questions, folks.

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